What is the foundation of the InnovAAte amino acid products?
The foundation of InnovAAte’s range of amino acid products originates from the companys’ chief scientists, Hugh Dunstan & Tim Roberts, spending three decades of leading research with collaborators from across the globe in the areas of chronic fatigue, sweat, protein, amino acids and metabolism.
In 2014 Hugh and Tim had a significant breakthrough when they were able to quantify the potential losses of amino acids by type and quantities in the sweat of athletes.
The following four years of research continued focussing on understanding the nature of amino acid losses in sweat from humans and horses. They have published their results in international peer-reviewed journals and have opened up a completely new understanding of protein turnover and amino acid metabolism in humans and horses.
This ground-breaking research is the underlying foundation of InnovAAte’s next generation of Amino Acid Biotechnology products. With a far greater understanding of these important aspects of human biology, InnovAAte products are set to assist many people, no matter where they are in their life journey.
What are the key findings from the sweat research?
The research has taken us to understand that the body loses six amino acids from sweat and urine at substantially faster rates than other amino acids. These six amino acids are referred to as the "high-demand" amino acids.
In addition to protein synthesis, these amino acids are also used in multiple aspects of metabolism, including:
- Hormone production
- Formation of neurotransmitters
- Formation of DNA
- Folate metabolism
The foundation of the InnovAAte product ranges involves the rationale to replenish the key group of amino acids which have been identified to be lost at disproportionately faster rates than others during daily exertion.
The rates of losses of these high-demand amino acids can be exacerbated under many conditions, such as:
- Living in warmer climates, especially with high humidity
- Increased physical exertion
- High-intensity training regimes, gym work, fitness training
- Endurance activities such as long walks or hikes, marathon runs, long cycle rides
- Sporting competitions
- Games such as rugby, football, hockey
- Tennis, cricket
- High demand body performances, dancing, gymnastics
- Long workdays, commutes, hectic lifestyles
- Recoveries from illness and injuries.
Why can’t the amino acids be made by the body to meet the demand, even if we have a good diet?
Some of these key amino acids are “essential” amino acids, which means the body cannot make them and we need to take them in from the diet. We can obtain these amino acids from the diet, but we would have to consume large quantities to replace the necessary proportions of the specific amino acids lost. It also means that the body has to undergo breakdown of some its own proteins (the catabolic response) at the recovery time to provide a supply of these amino acids until the food taken in is digested, which could take hours after exercise. It is more efficient to supply directly the key amino acids either during, or immediately after, exercise.
Some of these key amino acids can be made by the body, but under certain conditions of high intensity exercise and training, the body can’t make them sufficiently quickly to meet the demand of where and when the body needs these amino acids.
Under these conditions, these amino acids become “conditionally essential”.
What happens if the body cannot make the amino acids fast enough to support the basic or intense exertion?
When the supply levels of amino acids in the bloodstream begin to be reduced by exertion, the body instigates a “catabolic response” to break down the muscle proteins to provide what it needs when it needs it.
For example, the amino acid serine is lost in great abundances via sweat and urine and is also used broadly in general metabolism. If the body needs to top up supplies of serine during exertion, then the catabolism of endogenous proteins in muscle can release what is required.
The downside of this is that many of the other amino acid components present in the protein that is broken down are not required in the same quantities, and thus get utilised as an energy sources, converted to fats or excreted in the sweat and urine.
If we can supply precisely what is needed at the critical time that it is needed, then we can minimise the requirement for catabolism in the body and reduce wastage of other amino acids.